Anthony J. Muslin, MD
Director, Center for Cardiovascular Research

Douglas L. Mann, MD
Lewin Professor and Chief, Cardiovascular Division

Mission

Our mission is to improve the quality of life through cutting-edge basic and translational cardiovascular research. We provide an intellectually stimulating and creative environment for training and developing the next generation of researchers.

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Featured CCR Publications:

An unbised chemical biology screen identifies agents that modulate uptake of oxidized LDL by macrophages. Etzion Y, Hackett A, Proctor BM, Ren J, Nolan B, Ellenberger T, Muslin AJ. Circ Res. 2009 Jul 17;105(2):148-57.

Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury. Proctor BM, Jin X, Lupu TS, Muglia LJ, Semenkovich CF, Muslin AJ. Circulation. 2008 Aug 5;118(6):658-66.

Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands MS, Schaffer JE, Semenkovich CF, Ory DS. J Clin Invest. 2008 Jun;118(6):2281-90.

Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13807-12.

The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress. Brookheart RT, Michel CI, Listenberger LL, Ory DS, Schaffer JE. J Biol Chem. 2009 Mar 20;284(12):7446-54.

Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation. Crawford PA, Crowley JR, Sambandam N, Muegge BD, Costello EK, Hamady M, Knight R, Gordon JI. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11276-81.

Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy. Flagg TP, Cazorla O, Remedi MS, Haim TE, Tones MA, Bahinski A, Numann RE, Kovacs A, Schaffer JE, Nichols CG, Nerbonne JM. Circ Res . 2009 Jan 2;104(1):95-103.

Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy. Marionneau C, Brunet S, Flagg TP, Pilgram TK, Demolombe S, Nerbonne JM. Circ Res. 2008 Jun 6;102(11):1406-15. Epub 2008 May 1.

Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1. Flagg TP, Kurata HT, Masia R, Caputa G, Magnuson MA, Lefer DJ, Coetzee WA, Nichols CG. Circ Res. 2008 Dec 5;103(12):1458-65.

Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. Remedi MS, Kurata HT, Scott A, Wunderlich FT, Rother E, Kleinridders A, Tong A, Brüning JC, Koster JC, Nichols CG. Cell Metab. 2009 Feb;9(2):140-51.

Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease. Gates AC, Bernal-Mizrachi C, Chinault SL, Feng C, Schneider JG, Coleman T, Malone JP, Townsend RR, Chakravarthy MV, Semenkovich CF. Cell Metab. 2007 Dec;6(6):497-505.

Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. Chakravarthy MV, Zhu Y, López M, Yin L, Wozniak DF, Coleman T, Hu Z, Wolfgang M, Vidal-Puig A, Lane MD, Semenkovich CF. J Clin Invest. 2007 Sep; 117(9):2539-52.

Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Matkovich SJ, Van Booven DJ, Youker KA, Torre-Amione G, Diwan A, Eschenbacher WH, Dorn LE, Watson MA, Margulies KB, Dorn GW 2nd. Circulation. 2009 Mar 10;119(9):1263-71.

A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Liggett SB, Cresci S, Kelly RJ, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SL, Dorn GW 2nd. Nat Med. 2008 May;14(5):510-7.

Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice. Gropler MC, Harris TE, Hall AM, Wolins NE, Gross RW, Han X, Chen Z, Finck BN. J Biol Chem. 2009 Mar 13;284(11):6763-72.