Featured CCR Publications:

Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment. Wentz AE, d'Avignon DA, Weber ML, Cotter DG, Doherty JM, Kerns R, Nagarajan R, Reddy N, Sambandam N, Crawford PA. J Biol Chem. 2010 Aug 6;285(32):24447-56.

Obligate role for ketone body oxidation in neonatal metabolic homeostasis. Cotter DG, d'Avignon DA, Wentz AE, Weber ML, Crawford PA. J Biol Chem. 2011 Mar 4;286(9):6902-10

Hepatic steatosis, inflammation, and ER stress in mice maintained long-term on a very low-carbohydrate ketogenic diet. Garbow JR, Doherty JM, Schugar RC, Travers S, Weber ML, Wentz AE, Ezenwajiaku N, Cotter DG, Brunt EM, Crawford PA. Am J Physiol Gastrointest Liver Physiol. 2011 Mar 31. [Epub ahead of print] PMID: 21454445

Altered systemic ketone metabolism in advanced heart failure. Janardhan, A, Chen, J, Crawford PA. Tx Heart Inst J. In press.

Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. Etzion S, Etzion Y, DeBosch B, Crawford PA, Muslin AJ. J Mol Cell Cardiol. 2010 Dec;49(6):931-40.

Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication. Zhang Y, Kanter EM, Yamada KA. Cardiovasc Pathol. 2010 Nov-Dec;19(6):e233-40.

Identification of CaMKII phosphorylation sites in Connexin43 by high-resolution mass spectrometry. Huang RY, Laing JG, Kanter EM, Berthoud VM, Bao M, Rohrs HW, Townsend RR, Yamada KA. J Proteome Res. 2011 Mar 4;10(3):1098-109.

A PPARa promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes. Cresci S, Huss JM, Beitelshees AL, Jones PG, Minton MR, Dorn GW, Kelly DP, Spertus JA, McLeod HL. PLoS One. 2010 Sep 3;5(9):e12584.

The adverse impact of diabetes mellitus on left ventricular remodeling and function in patients with severe aortic stenosis. Lindman BR, Arnold SV, Madrazo JA, Zajarias A, Johnson SN, Pérez JE, Mann DL. Circ Heart Fail. 2011 May 1;4(3):286-92.

The Emerging Role of Small Non-coding RNAs in the Failing Heart: Big Hopes for Small Molecules. Mann DL. Cardiovasc Drugs Ther. 2011 Apr;25(2):149.

The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls. Mann DL. Circ Res. 2011 Apr 29;108(9):1133-45.

Role of MicroRNAs in Cardiac Remodeling and Heart Failure. Topkara VK, Mann DL. Cardiovasc Drugs Ther. 2011 Apr;25(2):171-82.

Clinical applications of miRNAs in cardiac remodeling and heart failure. Topkara VK, Mann DL. Per Med. 2010 Sep 1;7(5):531-548.

Therapeutic targeting of innate immunity in the failing heart. Topkara VK, Evans S, Zhang W, Epelman S, Staloch L, Barger PM, Mann DL. J Mol Cell Cardiol. 2010 Nov 10. [Epub ahead of print] PMID: 21074541

Innate immunity in the adult mammalian heart: for whom the cell tolls. Mann DL, Topkara VK, Evans S, Barger PM. Trans Am Clin Climatol Assoc. 2010;121:34-50; discussion 50-1.

Toll-like Receptor-mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-activated Receptor {gamma} Coactivator-1 (PGC-1) Signaling. Schilling J, Lai L, Sambandam N, Dey CE, Leone TC, Kelly DP. Circ Heart Fail. 2011 May 10. [Epub ahead of print] PMID: 21558447

How the (pediatric) heart works when it contracts application of left ventricular "isovolumic acceleration" as a load-independent index of contractility. Kovács SJ. J Am Coll Cardiol. 2011 Mar 1;57(9):1108-10.

The thermodynamics of diastole: kinematic modeling-based derivation of the P-V loop to transmitral flow energy relation with in vivo validation. Mossahebi S, Shmuylovich L, Kovács SJ. Am J Physiol Heart Circ Physiol. 2011 Feb;300(2):H514-21.

Vortex formation time-to-left ventricular early rapid filling relation: model-based prediction with echocardiographic validation. Ghosh E, Shmuylovich L, Kovács SJ. J Appl Physiol. 2010 Dec;109(6):1812-9.

A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. Jiang X, Sidhu R, Porter FD, Yanjanin NM, Speak AO, Taylor Te Vruchte D, Platt FM, Fujiwara H, Scherrer DE, Zhang J, Dietzen DJ, Schaffer JE, Ory DS. J Lipid Res. 2011 Apr 24. [Epub ahead of print] PMID: 21518695

Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Porter FD, Scherrer DE, Lanier MH, Langmade SJ, Molugu V, Gale SE, Olzeski D, Sidhu R, Dietzen DJ, Fu R, Wassif CA, Yanjanin NM, Marso SP, House J, Vite C, Schaffer JE, Ory DS. Sci Transl Med. 2010 Nov 3;2(56):56ra81.

ApoA-1 in diabetes: damaged goods. Ory DS, Schaffer JE. Diabetes. 2010 Oct;59(10):2358-9.

A fibrin-specific thrombolytic nanomedicine approach to acute ischemic stroke. Marsh JN, Hu G, Scott MJ, Zhang H, Goette MJ, Gaffney PJ, Caruthers SD, Wickline SA, Abendschein D, Lanza GM. Nanomedicine (Lond). 2011 Apr 20. [Epub ahead of print] PMID: 21506686

Genetic ablation of calcium-independent phospholipase A(2)beta causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine. Dietrich HH, Abendschein DR, Moon SH, Nayeb-Hashemi N, Mancuso DJ, Jenkins CM, Kaltenbronn KM, Blumer KJ, Turk J, Gross RW. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2208-20.

Repolarizing cardiac potassium channels: Multiple sites and mechanisms for CaMKII-mediated regulation. Nerbonne JM. Heart Rhythm. 2011 Jan 11. [Epub ahead of print] PMID: 21232627

Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy. Yang KC, Foeger NC, Marionneau C, Jay PY, McMullen JR, Nerbonne JM. J Physiol. 2010 Dec 15;588(Pt 24):5015-32.

Proteomic analysis highlights the molecular complexities of native Kv4 channel macromolecular complexes. Marionneau C, Townsend RR, Nerbonne JM. Semin Cell Dev Biol. 2011 Apr;22(2):145-52

Douglas L. Mann, MD
Lewin Professor and Chief, Cardiovascular Division;
Acting Director, Center for Cardiovascular Research

Mission
Our mission is to improve the quality of life through cutting-edge basic and translational cardiovascular research. We provide an intellectually stimulating and creative environment for training and developing the next generation of researchers.

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Featured CCR Publications (Continued):

Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons. Norris AJ, Foeger NC, Nerbonne JM. J Neurosci. 2010 Oct 13;30(41):13644-55.

Neuronal voltage-gated K+ (Kv) channels function in macromolecular complexes. Norris AJ, Foeger NC, Nerbonne JM. Neurosci Lett. 2010 Dec 10;486(2):73-7.

Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes. Foeger NC, Marionneau C, Nerbonne JM. J Biol Chem. 2010 Oct 22;285(43):33413-22.

p53 is required for chloroquine-induced atheroprotection but not insulin sensitization. Razani B, Feng C, Semenkovich CF. J Lipid Res. 2010 Jul;51(7):1738-46.

De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation. Wei X, Schneider JG, Shenouda SM, Lee A, Towler DA, Chakravarthy MV, Vita JA, Semenkovich CF. J Biol Chem. 2011 Jan 28;286(4):2933-45.

Macrophage fatty-acid synthase deficiency decreases diet-induced atherosclerosis. Schneider JG, Yang Z, Chakravarthy MV, Lodhi IJ, Wei X, Turk J, Semenkovich CF. J Biol Chem. 2010 Jul 23;285(30):23398-409

The genomic architecture of sporadic heart failure. Dorn GW 2nd. Circ Res. 2011 May 13;108(10):1270-83.

MicroRNAs in cardiac disease. Dorn GW 2nd. Transl Res. 2011 Apr;157(4):226-35.

MARF and Opa1 control mitochondrial and cardiac function in Drosophila. Dorn GW 2nd, Clark CF, Eschenbacher WH, Kang MY, Engelhard JT, Warner SJ, Matkovich SJ, Jowdy CC. Circ Res. 2011 Jan 7;108(1):12-7.

RISC RNA sequencing for context-specific identification of in vivo microRNA targets. Matkovich SJ, Van Booven DJ, Eschenbacher WH, Dorn GW 2nd. Circ Res. 2011 Jan 7;108(1):18-26

Receptor-independent cardiac protein kinase Calpha activation by calpain-mediated truncation of regulatory domains. Kang MY, Zhang Y, Matkovich SJ, Diwan A, Chishti AH, Dorn GW 2nd. Circ Res. 2010 Oct 1;107(7):903-12.

Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation. Cappola TP, Matkovich SJ, Wang W, van Booven D, Li M, Wang X, Qu L, Sweitzer NK, Fang JC, Reilly MP, Hakonarson H, Nerbonne JM, Dorn GW 2nd. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2456-61

TRB3 function in cardiac endoplasmic reticulum stress. Avery J, Etzion S, DeBosch BJ, Jin X, Lupu TS, Beitinjaneh B, Grand J, Kovacs A, Sambandam N, Muslin AJ. Circ Res. 2010 May 14;106(9):1516-23. Epub 2010 Apr 1.

Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier k channels by cholesterol. D'Avanzo N, Hyrc K, Enkvetchakul D, Covey DF, Nichols CG. PLoS One. 2011 Apr 29;6(4):e19393.

HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels. Zhang HX, Akrouh A, Kurata HT, Remedi MS, Lawton JS, Nichols CG. J Mol Cell Cardiol. 2011 Mar;50(3):552-60

Defects in beta cell Ca²+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus. Benninger RK, Remedi MS, Head WS, Ustione A, Piston DW, Nichols CG. Diabetologia. 2011 May;54(5):1087-97

Congenital hyperinsulinism and glucose hypersensitivity in homozygous and heterozygous carriers of Kir6.2 (KCNJ11) mutation V290M mutation: K(ATP) channel inactivation mechanism and clinical management. Loechner KJ, Akrouh A, Kurata HT, Dionisi-Vici C, Maiorana A, Pizzoferro M, Rufini V, de Ville de Goyet J, Colombo C, Barbetti F, Koster JC, Nichols CG. Diabetes. 2011 Jan;60(1):209-17

Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate. D'Avanzo N, Cheng WW, Doyle DA, Nichols CG. J Biol Chem. 2010 Nov 26;285(48):37129-32

Molecular mechanisms of EAST/SeSAME syndrome mutations in Kir4.1 (KCNJ10). Sala-Rabanal M, Kucheryavykh LY, Skatchkov SN, Eaton MJ, Nichols CG. J Biol Chem. 2010 Nov 12;285(46):36040-8.

Muscle KATP channels: recent insights to energy sensing and myoprotection. Flagg TP, Enkvetchakul D, Koster JC, Nichols CG. Physiol Rev. 2010 Jul;90(3):799-829.

Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response. Chambers KT, Leone TC, Sambandam N, Kovacs A, Wagg CS, Lopaschuk GD, Finck BN, Kelly DP. J Biol Chem. 2011 Apr 1;286(13):11155-62. Epub 2011 Feb 14.

Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis. Mitra MS, Schilling JD, Wang X, Jay PY, Huss JM, Su X, Finck BN. J Mol Cell Cardiol. 2011 Apr 28. [Epub ahead of print] PMID: 21549711

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B (CideB). Chen Z, Norris JY, Finck BN. J Biol Chem. 2010 Aug 20;285(34):25996-6004.